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IGF-1 and its modified synthetic versions such as Long R3 IGF-1, des(1-3)IGF-1, and R3-IGF-I, have mitogenic effects, which speed up cell replication in laboratory models of different tissues

Multiple studies have confirmed that antioxidants such as vitamins C and E and erythritol can mitigate the negative effects of oxidative stress on reproductive function, enhance the stability of the BTB, and protect sperm DNA from oxidative damage [336]

Potential Side Effects and Considerations Common Side Effects of GLP-1 Agonists GLP-1 receptor agonists, such as semaglutide and tirzepatide, are effective medications for managing obesity and type 2 diabetes

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(B) Overexpression of the GLP-1R enhanced adiponectin expression